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General Surface-Enhanced Raman Spectroscopy Method for Actively Capturing Target Molecules in Small Gaps

化学 拉曼光谱 表面增强拉曼光谱 光热治疗 纳米技术 分子 拉曼散射 组合化学 小分子 有机化学 材料科学 光学 生物化学 物理
作者
Meihong Ge,Pan Li,Guoliang Zhou,Siyu Chen,Wei Han,Feng Qin,Yuman Nie,Yaoxiong Wang,Miao Qin,Guang-Yao Huang,Shaofei Li,Yongtao Wang,Liangbao Yang,Zhong‐Qun Tian
出处
期刊:Journal of the American Chemical Society [American Chemical Society]
卷期号:143 (20): 7769-7776 被引量:121
标识
DOI:10.1021/jacs.1c02169
摘要

Over the past decade, many efforts have been devoted to designing and fabricating substrates for surface-enhanced Raman spectroscopy (SERS) with abundant hot spots to improve the sensitivity of detection. However, there have been many difficulties involved in causing molecules to enter hot spots actively or effectively. Here, we report a general SERS method for actively capturing target molecules in small gaps (hot spots) by constructing a nanocapillary pumping model. The ubiquity of hot spots and the inevitability of molecules entering them lights up all the hot spots and makes them effective. This general method can realize the highly sensitive detection of different types of molecules, including organic pollutants, drugs, poisons, toxins, pesticide residues, dyes, antibiotics, amino acids, antitumor drugs, explosives, and plasticizers. Additionally, in the dynamic detection process, an efficient and stable signal can be maintained for 1-2 min, which increases the practicality and operability of this method. Moreover, a dynamic detection process like this corresponds to the processes of material transformation in some organisms, so the method can be used to monitor transformation processes such as the death of a single cell caused by photothermal stimulation. Our method provides a novel pathway for generating hot spots that actively attract target molecules, and it can achieve general ultratrace detection of diverse substances and be applied to the study of cell behaviors in biological systems.
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