The effect of atropine 0.01% eyedrops on relative peripheral refraction in myopic children

睫状肌麻痹 阿托品 安慰剂 医学 折射误差 眼科 麻醉 外围设备 眼病 内科学 病理 替代医学
作者
Jiaxin Tian,Shifei Wei,Shi‐Ming Li,Wen An,Weiling Bai,Xintong Liang,Jiang Du,Ning Li Wang
出处
期刊:Eye [Springer Nature]
卷期号:37 (2): 356-361 被引量:5
标识
DOI:10.1038/s41433-021-01923-1
摘要

Relative peripheral refraction (RPR) is a significant factor that participates in myopic development. Here, we evaluated the effects of atropine 0.01% eyedrops, as an antimyopia drug, on RPR.Seventy-three children were enrolled from a randomized, double-blinded, placebo-0.01% atropine eyedrops cross-over trial. The study group had used the placebo for one year and then crossed over to atropine 0.01% eyedrops for half a year. The control group had used 0.01% atropine for one year and then crossed over to placebo eyedrops for half a year. Central and horizontal peripheral refractions (15° and 30° at the temporal and nasal retina) were measured under non-cycloplegia and cycloplegia.No significant differences in age, gender, and central refraction were identified between the two groups (P > 0.05). Under non-cycloplegia, the control group showed significant relative hyperopia in the temporal 30° retina and the nasal retina (P = 0.031; P < 0.001; P < 0.001). In the study group, the relative hyperopia in the temporal 30° retina disappeared (P = 0.983). After cycloplegia, the control group had less myopia in central refractions and less hyperopia in temporal RPR (P < 0.001; P = 0.039; P < 0.001). The study group did not present significant changes in central refractions and temporal RPR (P = 0.122; P = 0.222; P = 0.475).For myopic children, atropine 0.01% eyedrops can alleviate relative hyperopia in the temporal retina and the hyperopic shift before cycloplegia. The effect might participate in myopia control.
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