亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Moderate hypothermia in neonatal encephalopathy: Safety outcomes

医学 体温过低 麻醉 不利影响 脑病 心动过缓 凝血时间激活 内科学 心率 体外循环 血压
作者
Dorothea Jenkins Eicher,Carol L. Wagner,Lakshmi Katikaneni,Thomas C. Hulsey,W. Thomas Bass,David Kaufman,Michael J. Horgan,Sheila Languani,Jatinder Bhatia,Lawrence M. Givelichian,K Sankaran,Jerome Y. Yager
出处
期刊:Pediatric Neurology [Elsevier BV]
卷期号:32 (1): 18-24 被引量:207
标识
DOI:10.1016/j.pediatrneurol.2004.06.015
摘要

Hypoxic-ischemic injury may cause multisystem organ damage with significant aberrations in clotting, renal, and cardiac functions. Systemic hypothermia may aggravate these medical conditions, such as bradycardia and increased clotting times, and very little safety data in neonatal hypoxic-ischemic injury is available. This study reports a multicenter, randomized, controlled pilot trial of moderate systemic hypothermia (33°C) vs normothermia (37°C) for 48 hours in infants with neonatal encephalopathy instituted within 6 hours of birth or hypoxic-ischemic event. The best outcome measures of safety were determined, comparing rates of adverse events between normothermia and hypothermia groups. A total of 32 hypothermia and 33 normothermia neonates were enrolled in seven centers. Adverse events and serious adverse effects were collected by the study team during the hospital admission, monitored by an independent study monitor, and reported to Institutional Review Boards and the Data and Safety Monitoring Committee. The following adverse events were observed significantly more commonly in the hypothermia group: more frequent bradycardia and lower heart rates during the period of hypothermia, longer dependence on pressors, higher prothrombin times, and lower platelet counts with more patients requiring plasma and platelet transfusions. Seizures as an adverse event were more common in the hypothermia group. These observed side effects of 48 hours of moderate systemic hypothermia were of mild to moderate severity and manageable with minor interventions. Hypoxic-ischemic injury may cause multisystem organ damage with significant aberrations in clotting, renal, and cardiac functions. Systemic hypothermia may aggravate these medical conditions, such as bradycardia and increased clotting times, and very little safety data in neonatal hypoxic-ischemic injury is available. This study reports a multicenter, randomized, controlled pilot trial of moderate systemic hypothermia (33°C) vs normothermia (37°C) for 48 hours in infants with neonatal encephalopathy instituted within 6 hours of birth or hypoxic-ischemic event. The best outcome measures of safety were determined, comparing rates of adverse events between normothermia and hypothermia groups. A total of 32 hypothermia and 33 normothermia neonates were enrolled in seven centers. Adverse events and serious adverse effects were collected by the study team during the hospital admission, monitored by an independent study monitor, and reported to Institutional Review Boards and the Data and Safety Monitoring Committee. The following adverse events were observed significantly more commonly in the hypothermia group: more frequent bradycardia and lower heart rates during the period of hypothermia, longer dependence on pressors, higher prothrombin times, and lower platelet counts with more patients requiring plasma and platelet transfusions. Seizures as an adverse event were more common in the hypothermia group. These observed side effects of 48 hours of moderate systemic hypothermia were of mild to moderate severity and manageable with minor interventions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
El发布了新的文献求助10
6秒前
某个不想做人的dio完成签到 ,获得积分10
8秒前
冷静新烟发布了新的文献求助10
10秒前
Eden完成签到,获得积分10
11秒前
20秒前
烟花应助灵感大王喵采纳,获得200
21秒前
夏夏完成签到 ,获得积分10
24秒前
28秒前
29秒前
潘善若发布了新的文献求助10
33秒前
田様应助El采纳,获得10
35秒前
隔壁巷子里的劉完成签到 ,获得积分10
38秒前
李爱国应助潘善若采纳,获得10
42秒前
49秒前
五十一完成签到 ,获得积分10
57秒前
奇遇完成签到 ,获得积分10
58秒前
1分钟前
含糊的安柏完成签到,获得积分10
1分钟前
huihongzeng发布了新的文献求助10
1分钟前
NexusExplorer应助含糊的安柏采纳,获得10
1分钟前
1分钟前
冷静新烟完成签到,获得积分20
1分钟前
冷静新烟发布了新的文献求助10
1分钟前
简单山水发布了新的文献求助10
1分钟前
Novajet完成签到,获得积分10
1分钟前
yx_cheng应助归海浩阑采纳,获得30
1分钟前
ding应助科研通管家采纳,获得10
1分钟前
1分钟前
大碗完成签到 ,获得积分10
1分钟前
桐桐应助简单山水采纳,获得10
1分钟前
1分钟前
Novajet发布了新的文献求助10
1分钟前
小碗完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
黄桂斌完成签到,获得积分10
1分钟前
许三问完成签到 ,获得积分0
1分钟前
略略完成签到,获得积分10
1分钟前
情怀应助Novajet采纳,获得10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228