Copper(II) Sulfate

[7758-99-8] H10CuO9S (MW 249.68) InChI = 1S/Cu.H2O4S.5H2O/c;1-5(2,3)4;;;;;/h;(H2,1,2,3,4);5*1H2/q+2;;;;;;/p-2 InChIKey = JZCCFEFSEZPSOG-UHFFFAOYSA-L (Lewis acid catalyst for alcohol dehydration,1, 31 acetonide formation,6 acetal exchange,9 ketone,33 alcohol, and phenol34 protection, trans-esterification of β-ketoesters,36 imine37 and oxime38 formation, diazo-transfer,39 cleavage of N–O bonds,42 hydrolysis of imines,43 reductive amidation;44 reagent for formation of copper carbenoids,15 intramolecular and intermolecular cyclopropanations,21, 48 redox catalyst with potassium permanganate for oxidation of alcohols25, 53 and alkenes;28, 53 reagent for reduction of alkenes,59 oximes,60 and azides61 with sodium borohydride or hydrazine; reductive removal of diazo group,64 reductive dehydrazination,65 and amino acid complexation66). Physical Data: 110 °C, −4H2O; 150 °C, −5H2O; heating above 560 °C causes decomposition to CuO; d 2.28 g cm−3. Solubility: sol H2O and methanol; slightly sol ethanol; insol acetone and ether; anhyd form sol H2O, practically insol methanol and ethanol. Form Supplied in: blue solid, widely available. Drying: for certain applications, copper(II) sulfate must be used as an anhyd reagent; dehydration of CuSO4·5H2O can be accomplished by heating in an open porcelain dish at 275 °C for two days in a drying oven, stirring the sample several times during the drying period to break up any lumps; during this time the deep blue crystals are converted to an off-white powder. Handling, Storage, and Precautions: CuSO4·5H2O can be stored and handled in the laboratory using normal laboratory methods; anhyd CuSO4 is a powerful desiccant and must be stored out of contact with moisture, but can be weighed and transferred in the laboratory if atmospheric exposure is minimized; copper(II) sulfate is a strong irritant to the skin and mucous membranes.