Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology

医学 低钠血症 脑桥中央髓鞘溶解症 病理生理学 脑病 发病机制 营养不良 吞咽困难 弱点 韦尼克脑病 内科学 儿科 胃肠病学 外科
作者
Ravi Ambati,Lay Kun Kho,David Prentice,Andrew Thompson
出处
期刊:Internal Medicine Journal [Wiley]
卷期号:53 (7): 1154-1162 被引量:6
标识
DOI:10.1111/imj.15855
摘要

Osmotic demyelination syndrome (ODS) is non-inflammatory demyelination in response to an osmotic challenge. It can be pontine or extrapontine in presentation.To retrospectively review cases involving ODS and define the spectrum of causes, risk factors, clinical and radiological presentations, and functional outcomes.The study utilised data from 15 patients with a mean age of 53.6 years. Malnutrition (9; 60%) and chronic alcoholism (10; 66.7%) were the most common associated disorders. Two (13.3%) patients had severe hyponatraemia (<120 mmol/L). The average highest single-day change was 5.1 mmol/L. Radiologically, 14 (93.3%) had pontine and 6 (40%) had extra-pontine lesions. Hypokalaemia (14; 93.3%) and hypophosphataemia (9; 60%) were commonly associated. Common clinical manifestations include altered consciousness/encephalopathy (9; 60%), dysphagia (4; 26.7%) and limb weakness (4; 26.7%). At 3 months, two (14.3%) had died and six (40%) were functionally independent (modified Rankin scale 0-2).We found that ODS occurred despite appropriate correction rates of hyponatraemia. Factors such as malnutrition, chronic alcoholism, hypokalaemia and hypophosphataemia are thought to play a role in its pathogenesis. Approximately half of the patients survived and became functionally independent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
汉堡包应助keke采纳,获得10
刚刚
千寻未央发布了新的文献求助10
刚刚
刚刚
1秒前
Murphy发布了新的文献求助10
1秒前
2秒前
3秒前
飘逸踏歌完成签到,获得积分10
3秒前
3秒前
Wonderland发布了新的文献求助10
4秒前
我不吃葱完成签到,获得积分10
4秒前
zyd完成签到,获得积分10
4秒前
传奇3应助冷静映安采纳,获得10
4秒前
家颜完成签到,获得积分10
6秒前
英姑应助123采纳,获得10
6秒前
6秒前
谷粱靖柔发布了新的文献求助30
6秒前
超级气泡水发布了新的文献求助150
6秒前
月月发布了新的文献求助10
7秒前
serena发布了新的文献求助10
7秒前
wangzh发布了新的文献求助30
7秒前
7秒前
----完成签到,获得积分10
8秒前
67发布了新的文献求助10
8秒前
manbao完成签到,获得积分10
8秒前
小马甲应助安详的盼波采纳,获得10
8秒前
8秒前
grzzz完成签到,获得积分10
9秒前
方赫然应助Hou采纳,获得10
9秒前
所所应助Wen采纳,获得10
9秒前
9秒前
10秒前
10秒前
夏爽2023应助hh0采纳,获得10
11秒前
天天快乐应助谷粱靖柔采纳,获得10
11秒前
无花果应助王润采纳,获得10
11秒前
云瑾应助xxxx采纳,获得20
11秒前
科研通AI2S应助mariawang采纳,获得10
12秒前
LYP发布了新的文献求助10
12秒前
12秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245464
求助须知:如何正确求助?哪些是违规求助? 2889085
关于积分的说明 8256869
捐赠科研通 2557437
什么是DOI,文献DOI怎么找? 1386114
科研通“疑难数据库(出版商)”最低求助积分说明 650285
邀请新用户注册赠送积分活动 626541