Identifying Multiple Sclerosis Activity

Reverberating throughout neuro-ophthalmology training programs is an informal proverb that the eye is a window into the brain. Almost every neurologic disease may have an ocular manifestation. Multiple sclerosis (MS) is no exception and for retinal imaging has been the prototype application of optical coherence tomography (OCT) in neurologic disease. While publications demonstrating the utility of OCT outcomes as biomarkers in MS have exponentially increased over 20 years,1 the most critical results have emerged in the last few years, showing that OCT measures may have predictive value for disease course and may be sensitive to treatment effects.