Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial

心理学 匹兹堡睡眠质量指数 神经心理学 内科学 医学 肿瘤科 认知 神经科学 睡眠质量
作者
Ziying Yang,Wenbo Zhang,Dunxiu Liu,Shanshan Zhang,Yong Tang,Jinlin Song,Jinfeng Long,Jun Yang,Hong Jiang,Yaling Li,Xintong Liu,Yang Lü,Ding Fu
出处
期刊:Frontiers in Aging Neuroscience [Frontiers Media SA]
卷期号:14 被引量:6
标识
DOI:10.3389/fnagi.2022.910261
摘要

To investigate the effects of sport stacking on the overall cognition and brain function in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI).A single-blind randomized controlled design was performed using sport stacking for 30 min, 5 days/week for 12 weeks. Forty-eight subjects with mild AD or MCI were randomly divided into the sport stacking group (T-mAD = 12, T-MCI = 12) and the active control group (C-mAD = 11, C-MCI = 13). Auditory Verbal Learning Test (AVLT), Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL), Geriatric Depression Scale (GDS-30), and Pittsburgh Sleep Quality Index (PSQI) were performed, the level of amyloid β-protein-40 (Aβ-40), Aβ-42, brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1(IGF-1), tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6), and soluble trigger receptor expressed on myeloid cells 2 (sTREM2) in plasma were tested, and brain functional connectivity in resting state and activation under finger movement task were analyzed by functional near-infrared spectroscopy (fNIRS).Thirty-nine patients completed the trial. After 4 weeks, we found a significant increase in AVLT score in T-MCI (6.36 ± 5.08 vs. -1.11 ± 4.23, p = 0.004), and T-mAD group (4.60 ± 4.77 vs. -0.11 ± 2.89, p = 0.039). After 12 weeks, there was a significantly improved in AVLT (9.64 ± 4.90 vs. -0.33 ± 6.10, p = 0.002) and ADCS-ADL (3.36 ± 3.59 vs. -1.89 ± 2.71, p = 0.003) in T-MCI. There was a significant improvement in AVLT (5.30 ± 5.42 vs. 0.44 ± 2.40) in T-mAD (p < 0.05). Plasma levels of BDNF were upregulated in both T-MCI and T-mAD, and IGF-1 increased in T-MCI (P < 0.05) compared to the control groups. The functional connectivity in MCI patients between DLPFC.R and SCA.R, SMA.L, and SCA.R was decreased. In contrast, in mAD patients, the brain regional function connection was increased between DLPFC.R and Broca's.L. The activation of channel 36 located in the left primary somatosensory cortex was significantly increased after 12-week training, which was correlated with the improved AVLT and the increase of BDNF.Our findings suggested that sport stacking is effective for patients with MCI and mild AD, possibly through increasing the expression of neuroprotective growth factors and enhancing neural plasticity to improve neurocognitive performance.https://www.ClinicalTrials.gov, ChiCTR.org.cn, identifier: ChiCTR-2100045980.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
田様应助吃饭用大碗采纳,获得10
1秒前
1秒前
2秒前
3秒前
阿斯蒂和琴酒完成签到 ,获得积分10
3秒前
珂珂发布了新的文献求助10
5秒前
5秒前
迟大猫应助我是站长才怪采纳,获得30
5秒前
6秒前
BaekHyun发布了新的文献求助10
6秒前
背后翠梅发布了新的文献求助30
6秒前
CCR发布了新的文献求助10
6秒前
su发布了新的文献求助10
8秒前
善学以致用应助钰c采纳,获得10
8秒前
Fundamental完成签到,获得积分20
9秒前
通~发布了新的文献求助10
9秒前
Akim应助阿屁屁猪采纳,获得10
9秒前
10秒前
细雨听风发布了新的文献求助10
10秒前
10秒前
英俊的小松鼠完成签到,获得积分10
10秒前
11秒前
13秒前
cc完成签到,获得积分20
13秒前
14秒前
14秒前
背后翠梅完成签到,获得积分10
14秒前
14秒前
涛涛发布了新的文献求助10
14秒前
lan完成签到,获得积分10
14秒前
皮皮完成签到 ,获得积分10
15秒前
ChiDaiOLD完成签到,获得积分10
15秒前
15秒前
情怀应助顺顺采纳,获得10
15秒前
Fundamental发布了新的文献求助10
17秒前
咩咩发布了新的文献求助10
17秒前
kingmin应助金鸡奖采纳,获得10
17秒前
喜悦蚂蚁完成签到,获得积分10
18秒前
赘婿应助拼搏向前采纳,获得10
18秒前
18秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527928
求助须知:如何正确求助?哪些是违规求助? 3108040
关于积分的说明 9287614
捐赠科研通 2805836
什么是DOI,文献DOI怎么找? 1540070
邀请新用户注册赠送积分活动 716904
科研通“疑难数据库(出版商)”最低求助积分说明 709808