Human Amniotic Membrane Plug for Chronic or Persistent Macular Holes

To report on the use of human amniotic membrane for macular holes at 2 Canadian tertiary care centers.Retrospective cohort study.Twenty-two patients with persistent or chronic macular holes.Macular hole surgery was performed by 3 vitreoretinal surgeons.Macular hole closure with complete plugging by human amniotic membrane on spectral-domain OCT.The closure rate was 91% (20 of 22; median follow-up, 7 months), with no statistically significant visual acuity change overall. Complications included subretinal silicone oil (5%), choroidal neovascularization (5%), atrophy (5%), and cystoid macular edema (9%).Anatomical success with limited visual recovery was observed.