斑马鱼
高雄激素血症
生物
激素
内分泌系统
胰岛素抵抗
多囊卵巢
动物模型
生物信息学
内分泌学
内科学
医学
胰岛素
遗传学
基因
作者
Gokul Sudhakaran,Ajay Guru,B. Hari Deva Muthu,Raghul Murugan,Aziz Arshad,Jesu Arockiaraj
出处
期刊:Life Sciences
[Elsevier]
日期:2022-02-01
卷期号:291: 120276-120276
被引量:16
标识
DOI:10.1016/j.lfs.2021.120276
摘要
Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is still yet to be found. Multiple factors have increased PCOS prevalence, hyperandrogenism, oxidative stress, inflammation, and insulin resistance. Various animal PCOS models have been developed to imitate the pathophysiology of PCOS in humans. Zebrafish is one of the most versatile animal experimental models because of the transparency of the embryos, small size, and rapid growth. The zebrafish similarity to higher vertebrates made it a useful non-mammalian model for PCOS drug testing and screening. This review provides an insight into the usage of zebrafish, a non-mammalian model for PCOS, as an opportunity for evaluating future initiatives in such a research domain.
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