Induction Efficacy of Upadacitinib in Therapy-Refractory Crohn’s Disease: A Retrospective Case Series

Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Achieving clinical and endoscopic remission is the main therapeutic goal.1 Despite available treatment options, some patients present with treatment-refractory disease to approved therapies.2 Randomized clinical trials enable a standardized evaluation of drugs with new modes of action. However, eligibility criteria are strict excluding those with ostomy or failures to other medication leaving a considerable proportion of patients noneligible.3.