萜烯
赫拉
立体化学
卫矛科
化学
癌细胞系
二维核磁共振波谱
三萜
生物
癌症
癌细胞
细胞
生物化学
医学
病理
替代医学
遗传学
作者
Yuanyuan Huang,Lu Chen,Jing Yao,Xiaohan Jia,Fu-Sheng Deng,JingYa Mo,Yuan Ji
标识
DOI:10.1080/14786419.2021.2023870
摘要
Two new triterpenes, 3β, 7β-dihydroxyolean-12-en-11-one (1) and 3β-O-acetyl-7β-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3β-hydroxyolean-12-en-11-one (3), β-amyrin (4), lup-20(29)-ene-1β, 3β-diol (5) and 1β, 3β-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of Maytenus guangxiensis C. Y. Cheng et W. L. Sha. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and IR experiments. Compounds (3-6) were isolated from M. guangxiensis for the first time. Compounds 1-6 were evaluated for their antiproliferative activities against Eca-109, PANC-1, EJ and HeLa cell lines. The results showed that compounds 1-6 displayed a certain degree of inhibitory effects against the proliferation of various human cancer cell lines.
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