罗亚
神经退行性变
信号转导
小型GTPase
生物
GTP酶
细胞生物学
效应器
神经科学
疾病
医学
病理
作者
Sissel Ida Schmidt,Morten Blaabjerg,Kristine Freude,Morten Meyer
出处
期刊:Cells
[MDPI AG]
日期:2022-05-01
卷期号:11 (9): 1520-1520
被引量:40
标识
DOI:10.3390/cells11091520
摘要
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration.
科研通智能强力驱动
Strongly Powered by AbleSci AI