To review disease-related symptoms and side effects of treatment in patients with multiple myeloma (MM).Peer-reviewed articles, research studies, and clinical guidelines.New therapies provide patients with extended survival, but in many cases this benefit is counterbalanced by an increased incidence of side effects. Preservation of organ function, while managing side effects, is essential for the care of patients with MM.Disease- and treatment-related adverse events are prevalent in patients with MM. Patient, family, and health care professional education is essential to monitor and manage these side effects.