作者
Ganesh M. Shankar,Joshua M. Francis,Mikael L. Rinne,Shakti Ramkissoon,Franklin W. Huang,Andrew S. Venteicher,Elliot H. Akama‐Garren,Yun Jee Kang,Nina Lelic,James C. Kim,Loreal Brown,Sarah Charbonneau,Alexandra J. Golby,Chandra Sekhar Pedamallu,Mai P. Hoang,Ryan J. Sullivan,Andrew D. Cherniack,Levi A. Garraway,Anat Stemmer‐Rachamimov,David A. Reardon,Patrick Y. Wen,Priscilla K. Brastianos,William T. Curry,Frederick G. Barker,William C. Hahn,Brian V. Nahed,Keith L. Ligon,David N. Louis,Daniel P. Cahill,Matthew Meyerson
摘要
IMPORTANCE-Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma guides the decision to pursue definitive neurosurgical resection.Establishing the intraoperative diagnosis by histologic analysis can be difficult in low-cellularity infiltrative gliomas.Therefore, we developed a rapid and sensitive genotyping assay to detect somatic single-nucleotide variants in the telomerase reverse transcriptase (TERT) promoter and isocitrate dehydrogenase 1 (IDH1).