一氧化氮
氧化应激
活性氮物种
化学
抗氧化剂
活性氧
过氧亚硝酸盐
黄嘌呤氧化酶
脂质过氧化
氧化磷酸化
生物化学
细胞生物学
生物物理学
超氧化物
生物
酶
有机化学
作者
David A. Wink,Katrina M. Miranda,Michael Graham Espey,Ryszard Pluta,Sandra J. Hewett,Carol A. Colton,Michael P. Vitek,Martin Feelisch,Matthew B. Grisham
标识
DOI:10.1089/152308601300185179
摘要
The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress.
科研通智能强力驱动
Strongly Powered by AbleSci AI