抗血栓
混凝级联
医学
重症监护医学
凝结
直接凝血酶抑制剂的发现与发展
凝血酶生成
血栓形成
抗凝剂
凝血酶
内科学
血小板
作者
Mimi L. Quan,P.W. Glunz,Joanne M. Smallheer
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2017-01-01
卷期号:: 600-627
被引量:2
标识
DOI:10.1016/b978-0-12-409547-2.12433-3
摘要
Thrombosis is the leading cause of morbidity and mortality worldwide. Therefore, the control of blood coagulation has become a major target for new therapeutic intervention over the past two decades. Factor Xa and thrombin inhibitors, which target specific serine proteases in the coagulation cascade, represent a new generation of antithrombotic drugs with improved clinical benefit. Despite these newer antithrombotic agents, there remains a need for more efficacious medications with less bleeding. This review will cover the major findings in the quest for new antithrombotic agents that have published since 2006.
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