Association of Polysensitization, Allergic Multimorbidity, and Allergy Severity: A Cross-Sectional Study of School Children

医学 空气过敏原 过敏 哮喘 免疫学 免疫球蛋白E 横断面研究 过敏原 病理 抗体
作者
Eun Kyo Ha,Ji Hyeon Baek,So‐Yeon Lee,Yong Mean Park,Woo Kyung Kim,Youn Ho Sheen,Seung Jin Lee,Youngoh Bae,Jihyeon Kim,Kee‐Jae Lee,Kangmo Ahn,Ho‐Jang Kwon,Man Yong Han
出处
期刊:International Archives of Allergy and Immunology [Karger Publishers]
卷期号:171 (3-4): 251-260 被引量:42
标识
DOI:10.1159/000453034
摘要

<b><i>Background:</i></b> Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. <b><i>Methods:</i></b> This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with allergic multimorbidities (coexistence of 2 or more of the following allergic diseases: asthma, rhinitis, eczema, and conjunctivitis) and severity of allergic diseases was determined by ordinal logistic regression analysis. <b><i>Results:</i></b> The rate of polysensitization was 13.6% (<i>n</i> = 458, 95% CI 12.4-14.8) and that of allergic multimorbidity was 23.5% (<i>n</i> = 790, 95% CI 22.0-24.9). Children sensitized to more aeroallergens tended to have more allergic diseases (rho = 0.248, <i>p</i> < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11, <i>p</i> < 0.001). The number allergen classes to which a child was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). <b><i>Conclusion:</i></b> Polysensitization was weakly related to multimorbidity. However, the number of allergens to which a child is sensitized is related to the severity of IgE-mediated symptoms.
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