Frontal and temporal cortical functional recovery after electroconvulsive therapy for depression: A longitudinal functional near-infrared spectroscopy study

电休克疗法 功能近红外光谱 心理学 口语流利性测试 前额叶皮质 认知 萧条(经济学) 重性抑郁障碍 神经科学 功能磁共振成像 额叶 睡眠剥夺对认知功能的影响 大脑活动与冥想 神经心理学 脑电图 宏观经济学 经济
作者
Jinichi Hirano,Akihiro Takamiya,Bun Yamagata,Syogo Hotta,Yukiko Miyasaka,Shenghong Pu,Akira Iwanami,Hiroyuki Uchida,Masaru Mimura
出处
期刊:Journal of Psychiatric Research [Elsevier BV]
卷期号:91: 26-35 被引量:52
标识
DOI:10.1016/j.jpsychires.2017.02.018
摘要

While the efficacy and tolerability of electroconvulsive therapy (ECT) for depression has been well established, the acute effects of ECT on brain function remain unclear. Particularly, although cognitive dysfunction has been consistently observed after ECT, little is known about the extent and time course of ECT-induced brain functional changes, as observed during cognitive tasks. Considering the acute antidepressant effects of ECT on depression, aberrant brain functional responses during cognitive tasks in patients with depression may improve immediately after this treatment. To clarify changes in cortical functional responses to cognitive tasks following ECT, we used task-related functional near-infrared spectroscopy (NIRS) to assess 30 patients with major depressive disorder or bipolar depression before and after an ECT series, as well as 108 healthy controls. Prior to ECT, patients exhibited significantly smaller [oxy-Hb] values in the bilateral frontal cortex during a letter verbal fluency task (VFT) compared with healthy controls. We found a significant increase in [oxy-Hb] values in the bilateral frontal cortex during the VFT after ECT in the patient group. A decrease in depression severity was significantly correlated with an increase in [oxy-Hb] values in the right ventrolateral prefrontal cortex following ECT. This is the first NIRS study to evaluate brain functional changes before vs. after ECT. Impaired functional responses, observed during the cognitive task in depressed patients, were normalized after ECT. Thus, recovery from abnormal functional responses to cognitive tasks in the frontal brain regions may be associated with the acute therapeutic effects of ECT for depression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
斯文败类应助机智思真采纳,获得10
刚刚
刚刚
沉默惋庭完成签到,获得积分10
刚刚
LiuLiu发布了新的文献求助10
刚刚
朴实的面包完成签到,获得积分10
1秒前
君克渡发布了新的文献求助10
1秒前
2秒前
Beginner发布了新的文献求助10
2秒前
2秒前
斯文飞雪发布了新的文献求助10
4秒前
庞鲂应助xiaoGuo采纳,获得30
4秒前
小王完成签到 ,获得积分10
4秒前
Trueman发布了新的文献求助10
5秒前
6秒前
6秒前
Blessing完成签到 ,获得积分10
7秒前
感性的若云完成签到,获得积分10
8秒前
WPP发布了新的文献求助10
8秒前
难过千易发布了新的文献求助10
9秒前
Singularity应助177ycd采纳,获得10
9秒前
Lucas应助lllllllll采纳,获得10
9秒前
文盲完成签到,获得积分10
9秒前
10秒前
NIUBEN发布了新的文献求助10
10秒前
11秒前
田様应助情殇采纳,获得10
11秒前
小吕完成签到,获得积分10
12秒前
Lee发布了新的文献求助10
12秒前
12秒前
闾丘博超完成签到,获得积分10
13秒前
jeff发布了新的文献求助10
14秒前
14秒前
14秒前
14秒前
15秒前
15秒前
hui完成签到,获得积分20
15秒前
15秒前
16秒前
上官若男应助xiaoshuai采纳,获得10
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187