微流控
制作
毛细管作用
阀门执行机构
化学
纳米技术
频道(广播)
生物医学工程
计算机科学
执行机构
材料科学
工程类
人工智能
替代医学
复合材料
病理
医学
计算机网络
作者
Bowei Li,Yu Lijuan,Ji Qi,Longwen Fu,Peiqing Zhang,Lingxin Chen
标识
DOI:10.1021/acs.analchem.7b00726
摘要
This paper describes a novel strategy for fabricating the movable valve on paper-based microfluidic devices to manipulate capillary-driven fluids. The movable valve fabrication is first realized using hollow rivets as the holding center to control the paper channel in different layer movement that results in the channel's connection or disconnection. The relatively simple valve fabrication procedure is robust, versatile, and compatible with microfluidic paper-based analytical devices (μPADs) with differing levels of complexity. It is remarkable that the movable valve can be convenient and free to control fluid without the timing setting, advantages that make it user-friendly for untrained users to carry out the complex multistep operations. For the performance of the movable valve to be verified, several different designs of μPADs were tested and obtained with satisfactory results. In addition, in the proof-of-concept enzyme-linked immunosorbent assay experiments, we demonstrate the use of these valves in μPADs for the successful analysis of samples of carcino-embryonic antigen, showing good sensitivity and reproducibility. We hope this technique will open new avenues for the fabrication of paper-based valves in an easily adoptable and widely available way on μPADs and provide potential point-of-care applications in the future.
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