化学
运输机
钠
戒指(化学)
胆汁酸
立体化学
生物化学
有机化学
基因
作者
Contributor: Philip Kocienski
出处
期刊:Synfacts
[Georg Thieme Verlag KG]
日期:2006-02-21
卷期号:2006 (03): 0188-0188
标识
DOI:10.1055/s-2006-931946
摘要
An extensive analogue program identified benzothiepine I as a potent, crystalline, nonhygroscopic apical sodium-codependent bile acid transporter (ASBT) inhibitor as a potential drug for lowering serum LDL cholesterol. A remarkable step is the highly enantio- and diastereoselective ring closure of the aldehyde derived from F to benzothiepine G.
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