已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Comparison between Different Measures of Body Fat with Kidney Function Decline and Incident CKD

医学 腰围 人体测量学 体质指数 肾功能 肾脏疾病 泊松回归 人口 内科学 肥胖 糖尿病 内分泌学 环境卫生
作者
Magdalena Madero,Ronit Katz,Rachel A. Murphy,Anne B. Newman,Kushang V. Patel,Joachim H. Ix,Carmen A. Peralta,Suzanne Satterfield,Linda F. Fried,Michael G. Shlipak,Mark J. Sarnak
出处
期刊:Clinical Journal of The American Society of Nephrology [Lippincott Williams & Wilkins]
卷期号:12 (6): 893-903 被引量:92
标识
DOI:10.2215/cjn.07010716
摘要

Background and objectives Although anthropometric measures of body fat are associated with development of CKD, they may not be able to distinguish between various forms of fat and therefore may be less accurate than computed tomography (CT) measures. We compared the association of CT and anthropometric measures of obesity with kidney outcomes in the Health Aging and Body Composition Study. Design, setting, participants, & measurements Participants were recruited from March of 1997 through July of 1998. CT measures included visceral abdominal fat (VAT), subcutaneous adipose tissue (SAT), and intermuscular fat area (IMAT), whereas anthropometric measures included waist circumference (WC) and body mass index (BMI). Kidney outcomes included kidney function (KF) decline (30% decrease in eGFR cysC in follow-up at either year 3 or 10) or incident CKD (follow-up eGFR cysC ≤60 ml/min per 1.73 m 2 in individuals with baseline GFR>60 ml/min per 1.73 m 2 ). Multivariable logistic regression models and Poisson regression models were used to evaluate the association with decline in KF and incident kidney disease, respectively. We also assessed for the independent associations among the exposure measures by including them in the same model. Results Two-thousand four-hundred and eighty-nine individuals were included. Mean age was 74±3 years, 49% were men, 39% were black, 59% were hypertensive, and 15% were diabetic. KF decline occurred in 17% of the population, whereas incident CKD also occurred in 17% of those at risk. In continuous models, SAT, VAT, IMAT, BMI, and WC (per SD increase) were all significantly associated with KF decline. There was a significant interaction between VAT and CKD with regard to KF decline ( P =0.01). Only VAT, BMI, and WC were associated with incident CKD. Only VAT remained a significant risk factor for incident CKD when other exposure variables were included in the same model. There was no association between any measure of obesity and kidney outcomes when creatinine values at years 3 and 10 were used to estimate changes in eGFR. Conclusions Anthropometric measures of body fat appear to provide as consistent estimates of KF decline risk as CT measures in elders.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
黎乐荷发布了新的文献求助10
1秒前
lee完成签到 ,获得积分10
2秒前
真的不会完成签到,获得积分10
3秒前
顺其自然_666888完成签到,获得积分10
4秒前
庾稀完成签到,获得积分20
5秒前
风一样的风干肠完成签到,获得积分10
6秒前
FODCOC完成签到,获得积分10
6秒前
Bowman完成签到,获得积分10
6秒前
大才完成签到,获得积分10
7秒前
L_MD完成签到,获得积分10
9秒前
melon完成签到,获得积分10
10秒前
所所应助发粪涂墙采纳,获得10
11秒前
JacekYu完成签到 ,获得积分10
12秒前
8D完成签到,获得积分10
12秒前
13秒前
小文子完成签到 ,获得积分10
14秒前
mingming发布了新的文献求助10
16秒前
虾虾完成签到 ,获得积分10
17秒前
wch完成签到 ,获得积分10
17秒前
王一g完成签到 ,获得积分10
18秒前
朴素的不乐完成签到 ,获得积分10
20秒前
20秒前
发粪涂墙完成签到,获得积分10
22秒前
陈欣瑶完成签到 ,获得积分10
23秒前
脑洞疼应助麦子采纳,获得10
23秒前
笑点低的大有完成签到 ,获得积分10
24秒前
发粪涂墙发布了新的文献求助10
26秒前
端庄半凡完成签到 ,获得积分10
27秒前
orixero应助mingming采纳,获得10
27秒前
李爱国应助krajicek采纳,获得10
27秒前
Rondab应助️语采纳,获得200
28秒前
大胆灵竹完成签到,获得积分20
29秒前
DSUNNY完成签到 ,获得积分10
29秒前
leeSongha完成签到 ,获得积分10
29秒前
jiamei_wen完成签到 ,获得积分10
30秒前
sci完成签到 ,获得积分10
30秒前
cndxh完成签到 ,获得积分10
30秒前
大力的宝川完成签到 ,获得积分10
30秒前
晚芦完成签到,获得积分10
31秒前
风鱼完成签到 ,获得积分10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989957
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11255966
捐赠科研通 3270856
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882252
科研通“疑难数据库(出版商)”最低求助积分说明 809216