伊萨丁
化学
抗菌剂
抗菌活性
金黄色葡萄球菌
大肠杆菌
效力
部分
席夫碱
组合化学
生物活性
有机化学
核化学
立体化学
细菌
体外
生物化学
遗传学
基因
生物
作者
Sumitra Nain,Garima Mathur,Tulika Anthwal,Swapnil Sharma,Sarvesh Paliwal
标识
DOI:10.1007/s11094-023-02867-4
摘要
1H-indol-2,3-dione (isatin) class of biologically active compounds have analgesic, anti-microbial, anti-inflammatory, anti-tubercular, anti-proliferative properties, and is also useful for the treatment of SARS-CoV. Schiff bases containing isatin moiety are known to have broad spectrum of biological activities like anti-viral, anti-tubercular, anti-fungal, and anti-bacterial. In this work, several Schiff base derivatives have been synthesized using two methods (synthetic and microwave) by reacting isatin with o-phenylenediamine. The synthesized compounds were structurally characterized and their in-vivo antimicrobial activity was tested against Gram-negative and Gram-positive bacteria using the inhibition zone method. Several newly synthesized isatin derivatives were found effective as antimicrobial agents and showed good potency (compounds 3c, 3d, 6a, 6b, 6d). Compound 3c displayed higher antimicrobial activity than standard drug (Amoxicillin) against Staphylococcus aureus at higher concentration (16 μg/mL) and against Escherichia coli at lower concentration (1 μg/mL).
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