凝血病
创伤性脑损伤
医学
重症监护医学
外伤
凝结
生物信息学
分子医学
神经科学
癌症
生物
精神科
内科学
外科
细胞周期
作者
Hongqiao Hou,Zhe Qu,Ruping Liu,Bowen Jiang,Lanlan Wang,Aiqun Li
出处
期刊:Biomedical Reports
[Spandidos Publications]
日期:2024-08-27
卷期号:21 (5)
摘要
Trauma is a prevalent cause of coagulopathy, with traumatic brain injury (TBI) accompanied by coagulation disorders particularly linked to adverse outcomes. TBI is distinguished by minimal bleeding volume and unique injury sites, which precipitate complex coagulation disturbances. Historically, research into trauma‑induced coagulopathy has primarily concentrated on the molecular biology and pathophysiology of endogenous anticoagulation and inflammation. Nonetheless, recognizing that cells are the fundamental units of structure and function in all living organisms, the present review aimed to distill our understanding of coagulopathy post‑TBI by elucidating the intricate cellular mechanisms involving endothelial cells, neutrophils and platelets. Additionally, this study evaluates the strengths and weaknesses of various diagnostic tools and discusses the characteristics of pharmacological treatments and potential therapies for patients with TBI and coagulation disorders. The aim of this review is to amalgamate recent updates in mechanistic research and innovative diagnostic and therapeutic methodologies, thereby fostering the progression of precision medicine within this specialized domain.
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