生物
同源重组
同源染色体
重组
复制(统计)
遗传学
进化生物学
DNA
基因
病毒学
作者
Michael Triplett,M. J. Johnson,Lorraine S. Symington
出处
期刊:DNA Repair
[Elsevier]
日期:2024-08-16
卷期号:142: 103753-103753
标识
DOI:10.1016/j.dnarep.2024.103753
摘要
DNA replication stress is one of the primary causes of genome instability. In response to replication stress, cells can employ replication restart mechanisms that rely on homologous recombination to resume replication fork progression and preserve genome integrity. In this review, we provide an overview of various methods that have been developed to induce site-specific replication fork stalling or collapse in eukaryotic cells. In particular, we highlight recent studies of mechanisms of replication-associated recombination resulting from site-specific protein-DNA barriers and single-strand breaks, and we discuss the contributions of these findings to our understanding of the consequences of these forms of stress on genome stability.
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