表观遗传学
DNA甲基化
生物
串扰
肝纤维化
癌症研究
纤维化
甲基化
生物信息学
计算生物学
遗传学
DNA
基因
医学
病理
基因表达
物理
光学
作者
Qi-Qi Dong,Yang Yang,Hui Tao,Chao Lu,H. J. Yang
标识
DOI:10.1016/j.cellsig.2024.111302
摘要
Liver fibrosis is a pathological process caused by a variety of chronic liver diseases. Currently, therapeutic options for liver fibrosis are very limited, highlighting the urgent need to explore new treatment approaches. Epigenetic modifications and epitranscriptomic modifications, as reversible regulatory mechanisms, are involved in the development of liver fibrosis. In recent years, researches in epitranscriptomics and epigenetics have opened new perspectives for understanding the pathogenesis of liver fibrosis. Exploring the epigenetic mechanisms of liver fibrosis may provide valuable insights into the development of new therapies for chronic liver diseases. This review primarily focus on the regulatory mechanisms of N6-methyladenosine (m6A) modification, non-coding RNA, and DNA methylation in organ fibrosis. It discusses the interactions between m6A modification and DNA methylation, as well as between m6A modification and non-coding RNA, providing a reference for understanding the interplay between epitranscriptomics and epigenetics.
科研通智能强力驱动
Strongly Powered by AbleSci AI