Systematic Prostate Biopsy Versus Perilesional Sampling: If It Isn’t Broke, Why Fix It?

The 2024 EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines for prostate cancer recommend a targeted and perilesional biopsy (TPLBx) strategy for primary diagnosis. In comparison to the classical approach of combined targeted and systematic biopsy, TPLBx may reduce overdiagnosis of insignificant cancers and mitigate the grade shift associated with targeted biopsy.