作者
Joshua Wollam,Michelle Solomon,Christiane Villescaz,Marion Lanier,Samantha Evans,Charles W. Bacon,David E. Freeman,Christiane Villescaz,Alan Vest,Jim Napora,Brittney Charlot,Christine Cavarlez,Andrew Kim,Lisa Dvorak,Brandon Selfridge,Li‐Min Huang,Andres Nevarez,Harry Dedman,Christiane Villescaz,Christiane Villescaz,Martin Metz,Nadine Serhan,Christiane Villescaz,Gregg Timony,Esther Martinborough,Marcus F. Boehm,Veena Viswanath
摘要
Mas-related G-protein coupled receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent degranulation and has been implicated in multiple mast cell-mediated disorders, including chronic urticaria, atopic dermatitis, and pain disorders. Although it is a promising therapeutic target, few potent, selective, small molecule antagonists have been identified, and functional effects of human MRGPRX2 inhibition have not been evaluated in vivo.