脂肪肝
TBARS公司
化学
抗氧化剂
内科学
脂肪生成
背景(考古学)
果糖
内分泌学
药理学
脂肪酸合酶
血脂谱
脂质代谢
胆固醇
脂质过氧化
医学
生物化学
生物
疾病
古生物学
作者
Luana Cristina Faria Carvalho,Flávia Monteiro Ferreira,Bruna Vidal Dias,Daniela Couto de Azevedo,Gustavo Henrique Bianco de Souza,Matheus Marque Milagre,Marta de Lana,Paula Melo de Abreu Vieira,Cláudia Martins Carneiro,Sílvia Paula-Gomes,Sílvia Dantas Cangussú,Daniela Caldeira Costa
标识
DOI:10.1080/13813455.2022.2138445
摘要
Context The role of silymarin in hepatic lipid dysfunction and its possible mechanisms of action were investigated.Objective To evaluate the effects of silymarin on hepatic and metabolic profiles in mice fed with 30% fructose for 8 weeks.Methods We evaluated the antioxidant profile of silymarin; mice consumed 30% fructose and were treated with silymarin (120 mg/kg/day or 240 mg/kg/day). We performed biochemical, redox status, and histopathological assays. RT-qPCR was performed to detect ACC-1, ACC-2, FAS, and CS expression, and western blotting to detect PGC-1α levels.Results Silymarin contains high levels of phenolic compounds and flavonoids and exhibited significant antioxidant capacity in vitro. In vivo, the fructose-fed groups showed increased levels of AST, ALT, SOD/CAT, TBARS, hepatic TG, and cholesterol, as well as hypertriglyceridaemia, hypercholesterolaemia, and increased ACC-1 and FAS. Silymarin treatment reduced these parameters and increased mRNA levels and activity of hepatic citrate synthase.Conclusions These results suggest that silymarin reduces worsening of NAFLD.
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