Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

材料科学 纳米技术 生物标志物 纳米医学 医学 疾病 重症监护医学 病理 生物 生物化学 纳米颗粒
作者
Qinrui Fu,Leilei Yu,Yin Wang,Peifeng Li,Jibin Song
出处
期刊:Advanced Functional Materials [Wiley]
卷期号:33 (2) 被引量:24
标识
DOI:10.1002/adfm.202206300
摘要

Abstract Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics are innovative strategies that enable the integration of diagnostic and therapeutic properties into a single nanosystem. Despite great success in nanotheranostics, their applications of nanotheranostics in nanomedicine are still in their infancy. This is because each disease has its corresponding characteristic pathological microenvironment, which motivates the development of endogenous biomarker‐responsive nanosystems to meet the requirements of diagnosis and treatment. Herein, recent progress is presented in biomarker‐responsive nanosystems and their biomedical applications. First, biomarker‐responsive nanosystems are classified into eight subsections according to the type of chronic diseases, including tumors, cardiovascular diseases, neurological diseases, Wilson's diseases, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis. In the following, a variety of intriguing applications of biomarkers‐responsive nanosystems are briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, and early evaluation of therapy effect, etc. Finally, the challenges and future directions from research to clinical translation of these responsive nanosystems are also presented.
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