Phosphatidylcholine Liposome Accelerated Platinum Nanomachines (PLANEs) With Enhanced Penetration Capability for Thrombus Mechanotherapy

Abstract Thrombotic cardiovascular diseases remain the leading cause of mortality worldwide. However, current thrombolytic therapeutics suffer from limited efficacy and a high risk of severe bleeding. Here, a phosphatidylcholine liposome accelerated platinum nanomachine (PLANE) for thrombus mechanotherapy is designed, constructed by encapsulating platinum nanomotors within isotropic, lubricating phosphatidylcholine (PC) liposomes. The precisely engineered PLANE exhibits superior lubricity and linear motion. Under laser irradiation and hydrogen peroxide treatment, PLANEs achieve significantly higher velocities than conventional platinum nanomotors, facilitating deep penetration into the thrombi. Further functionalization with thrombus‐targeting peptides enables the cPLANEs to selectively accumulate at the thrombotic sites in vivo, demonstrating excellent thrombolytic efficacy. This work presents a novel surface modification strategy for optimizing the motion behavior of platinum nanomotors, offering a promising non‐pharmaceutic approach for thrombotic disease treatment.