清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals

危险系数 痴呆 前瞻性队列研究 医学 比例危险模型 肺活量测定 内科学 队列 人口 队列研究 肺活量 鹿特丹研究 心脏病学 置信区间 疾病 肺功能 扩散能力 哮喘 环境卫生
作者
Ya‐Hui Ma,Ling-Xiao Shen,Yuzhu Li,Yue Leng,Yang Liu,Shi-Dong Chen,Xiao‐Yu He,Ya-Ru Zhang,Renjie Chen,Jianfeng Feng,Lan Tan,Qiang Dong,John Suckling,A David Smith,Wei Cheng,Jin-Tai Yu
出处
期刊:Brain Behavior and Immunity [Elsevier BV]
卷期号:109: 321-330 被引量:22
标识
DOI:10.1016/j.bbi.2023.02.009
摘要

Whether lung function prospectively affects cognitive brain health independent of their overlapping factors remains largely unknown. This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms. This population-based cohort included 43,1834 non-demented participants with spirometry from the UK Biobank. Cox proportional hazard models were fitted to estimate the risk of incident dementia for individuals with low lung function. Mediation models were regressed to explore the underlying mechanisms driven by inflammatory markers, oxygen-carrying indices, metabolites, and brain structures. During a follow-up of 3,736,181 person-years (mean follow-up 8.65 years), 5,622 participants (1.30 %) developed all-cause dementia, which consisted of 2,511 Alzheimer's dementia (AD) and 1,308 Vascular Dementia (VD) cases. Per unit decrease in lung function measure was each associated with increased risk for all-cause dementia (forced expiratory volume in 1 s [liter]: hazard ratio [HR, 95 %CI], 1.24 [1.14–1.34], P = 1.10 × 10-07; forced vital capacity [liter]: 1.16 [1.08–1.24], P = 2.04 × 10-05; peak expiratory flow [liter/min]: 1.0013 [1.0010–1.0017], P = 2.73 × 10-13). Low lung function generated similar hazard estimates for AD and VD risks. As underlying biological mechanisms, systematic inflammatory markers, oxygen-carrying indices, and specific metabolites mediated the effects of lung function on dementia risks. Besides, brain grey and white matter patterns mostly affected in dementia were substantially changed with lung function. Life-course risk for incident dementia was modulated by individual lung function. Maintaining optimal lung function is useful for healthy aging and dementia prevention.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
爆米花应助彦嘉采纳,获得10
20秒前
32秒前
ceeray23发布了新的文献求助20
35秒前
zpc猪猪完成签到,获得积分10
36秒前
Jenny发布了新的文献求助50
41秒前
香蕉觅云应助ceeray23采纳,获得20
56秒前
hoshi完成签到 ,获得积分10
1分钟前
woxinyouyou完成签到,获得积分0
1分钟前
思源应助方俊驰采纳,获得10
1分钟前
yuyuyu完成签到 ,获得积分10
1分钟前
1分钟前
方俊驰发布了新的文献求助10
1分钟前
方俊驰完成签到,获得积分10
1分钟前
1分钟前
ceeray23发布了新的文献求助20
1分钟前
研友_8y2G0L完成签到,获得积分10
1分钟前
liwang9301完成签到,获得积分10
2分钟前
2分钟前
2分钟前
lyj完成签到 ,获得积分10
2分钟前
Xuancheng_SINH完成签到,获得积分10
2分钟前
郭俊秀完成签到 ,获得积分10
2分钟前
2分钟前
ChatGPT发布了新的文献求助10
2分钟前
披着羊皮的狼完成签到 ,获得积分10
3分钟前
隐形曼青应助科研通管家采纳,获得10
3分钟前
ceeray23发布了新的文献求助20
3分钟前
orixero应助ceeray23采纳,获得20
4分钟前
1233发布了新的文献求助10
4分钟前
ChatGPT发布了新的文献求助10
4分钟前
JG完成签到 ,获得积分10
4分钟前
jkaaa完成签到,获得积分10
4分钟前
1233完成签到,获得积分10
4分钟前
太清完成签到 ,获得积分10
4分钟前
4分钟前
ceeray23发布了新的文献求助20
4分钟前
cadcae完成签到,获得积分10
4分钟前
Eric800824完成签到 ,获得积分10
4分钟前
庚朝年完成签到 ,获得积分10
4分钟前
violetlishu完成签到 ,获得积分10
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990550
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256532
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234