Ends end it via mitochondria: A telomere-dependent tumor suppressive mechanism acts during replicative crisis

Nassour et al. 1 Nassour J. Aguiar L.G. Correia A. Schmidt T.T. Mainz L. Przetocka S. Haggblom C. Tadepalle N. Williams A. Shokhirev M.N. et al. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. Nature. 2023; 614: 767-773https://doi.org/10.1038/s41586-023-05710-8 Crossref PubMed Scopus (15) Google Scholar report that telomere dysfunction communicates with mitochondria via the ZBP1-TERRA-MAVS axis. This pathway activates a detrimental innate immune response that may promote the elimination of cells prone to oncogenic transformation during replicative crisis, thus serving as a telomere-dependent tumor-suppressive mechanism. Nassour et al. 1 Nassour J. Aguiar L.G. Correia A. Schmidt T.T. Mainz L. Przetocka S. Haggblom C. Tadepalle N. Williams A. Shokhirev M.N. et al. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. Nature. 2023; 614: 767-773https://doi.org/10.1038/s41586-023-05710-8 Crossref PubMed Scopus (15) Google Scholar report that telomere dysfunction communicates with mitochondria via the ZBP1-TERRA-MAVS axis. This pathway activates a detrimental innate immune response that may promote the elimination of cells prone to oncogenic transformation during replicative crisis, thus serving as a telomere-dependent tumor-suppressive mechanism.