Entecavir versus tenofovir on the recurrence of hepatitis B–related HCC after liver transplantation: A multicenter observational study

医学 恩替卡韦 倾向得分匹配 肝细胞癌 内科学 肝移植 胃肠病学 比例危险模型 乙型肝炎 移植 观察研究 乙型肝炎病毒 拉米夫定 免疫学 病毒
作者
Deok Gie Kim,YoungRok Choi,Jinsoo Rhu,Shin Hwang,Young Kyoung You,Dong‐Sik Kim,Yang Won Nah,Bong‐Wan Kim,Jai Young Cho,Koo Jeong Kang,Jae Do Yang,Dong Lak Choi,Dong Jin Joo,Myoung Soo Kim,Je Ho Ryu,Jae Geun Lee
出处
期刊:Liver Transplantation [Lippincott Williams & Wilkins]
被引量:1
标识
DOI:10.1097/lvt.0000000000000227
摘要

Considerable controversy exists regarding the superiority of tenofovir disoproxil fumarate (TDF) over entecavir (ETV) for reducing the risk of HCC. This study aimed to compare outcomes of ETV versus TDF after liver transplantation (LT) in patients with HBV-related HCC. We performed a multicenter observational study using data from the Korean Organ Transplantation Registry. A total of 845 patients who underwent LT for HBV-related HCC were divided into 2 groups according to oral nucleos(t)ide analogue used for HBV prophylaxis post-LT: ETV group (n = 393) and TDF group (n = 452). HCC recurrence and overall death were compared in naïve and propensity score (PS)-weighted populations, and the likelihood of these outcomes according to the use of ETV or TDF were analyzed with various Cox models. At 1, 3, and 5 years, the ETV and TDF groups had similar HCC recurrence-free survival (90.7%, 85.6%, and 84.1% vs. 90.9%, 84.6%, and 84.2%, respectively, p = 0.98) and overall survival (98.4%, 94.7%, and 93.5% vs. 99.3%, 95.8%, and 94.9%, respectively, p = 0.48). The propensity score-weighted population showed similar results. In Cox models involving covariates adjustment, propensity score-weighting, competing risk regression, and time-dependent covariates adjustment, both groups showed a similar risk of HCC recurrence and overall death. In subgroup analyses stratified according to HCC burden (Milan criteria, Up-to-7 criteria, French alpha-fetoprotein risk score), pretransplantation locoregional therapy, and salvage LT, neither ETV nor TDF was superior. In conclusion, ETV and TDF showed mutual noninferiority for HCC outcomes when used for HBV prophylaxis after LT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
MS903完成签到,获得积分10
4秒前
CJW完成签到 ,获得积分10
5秒前
韧迹完成签到 ,获得积分0
5秒前
mmd完成签到 ,获得积分10
5秒前
七一安完成签到 ,获得积分10
6秒前
浪麻麻完成签到 ,获得积分10
10秒前
包容的剑完成签到 ,获得积分10
14秒前
等待的大炮完成签到,获得积分10
14秒前
注水萝卜完成签到 ,获得积分10
16秒前
Chem34完成签到,获得积分10
24秒前
26秒前
量子星尘发布了新的文献求助10
26秒前
hhh2018687完成签到,获得积分10
26秒前
26秒前
27秒前
27秒前
27秒前
27秒前
28秒前
28秒前
28秒前
28秒前
28秒前
28秒前
28秒前
嘒彼小星完成签到 ,获得积分10
28秒前
28秒前
29秒前
29秒前
29秒前
29秒前
30秒前
ri_290完成签到,获得积分10
30秒前
31秒前
nsc发布了新的文献求助30
33秒前
nsc发布了新的文献求助10
33秒前
nsc发布了新的文献求助10
33秒前
nsc发布了新的文献求助10
33秒前
nsc发布了新的文献求助10
33秒前
nsc发布了新的文献求助10
33秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022