炎症体
炎症
免疫学
先天免疫系统
半胱氨酸蛋白酶1
免疫系统
医学
疾病
关节炎
吡喃结构域
病理
作者
Ying Chen,X Ye,Germaine Escames,Wangrui Lei,Xin Zhang,Meng Li,Tong Jing,Yu Yao,Zhangwei Qiu,Zheng Wang,Darı́o Acuña-Castroviejo,Yang Yang
标识
DOI:10.1186/s11658-023-00462-9
摘要
Abstract The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.
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