神经病理性疼痛
脊髓
医学
代谢组学
生物
生物信息学
神经科学
麻醉
作者
Zihao Wu,Yuying Zhao,Sha Hao,Beibei Dong,Yi Zheng,Bin Liu,Jing Li
标识
DOI:10.1016/j.brainresbull.2024.110943
摘要
Existing evidence suggests that the composition of the gut microbiota is associated with neuropathic pain (NP), but the mechanistic link is elusive. Peroxisome proliferator-activated receptor α (PPARα) has been shown to be a pharmacological target for the treatment of metabolic disorders, and its expression is also involved in inflammatory regulation. The aim of this study was to investigate the important modulatory effects of PPARα on gut microbiota and spinal cord metabolites in mice subjected to chronic constriction injury.
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