Bisphenols can promote antibiotic resistance by inducing metabolic adaptations and natural transformation

细菌 质粒 代谢途径 抗生素耐药性 抗生素 转化(遗传学) 微生物群 化学 微生物学 生物 遗传学 生物化学 基因
作者
Jingyu Qin,Xin Qi,Yuejiao Li,Zhuyun Tang,Xiaona Zhang,Shaoguo Ru,Jiu-Qiang Xiong
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:470: 134149-134149 被引量:8
标识
DOI:10.1016/j.jhazmat.2024.134149
摘要

Whether bisphenols, as plasticizers, can influence bacterial uptake of antibiotic resistance genes (ARGs) in natural environment, as well as the underlying mechanism remains largely unknow. Our results showed that four commonly used bisphenols (bisphenol A, S, F, and AF) at environmental relative concentrations can significantly promote transmission of ARGs by 2.97-3.56 times in Acinetobacter baylyi ADP1. Intriguingly, we observed ADP1 acquired resistance by integrating plasmids uptake and cellular metabolic adaptations other than through reactive oxygen species mediated pathway. Metabolic adaptations including upregulation of capsules polysaccharide biosynthesis and intracellularly metabolic enzymes, which enabled formation of thicker capsules for capturing free plasmids, and degradation of accumulated compounds. Simultaneously, genes encoding DNA uptake and translocation machinery were incorporated to enhance natural transformation of antibiotic resistance carrying plasmids. We further exposed aquatic fish to bisphenols for 120 days to monitor their long-term effects in aquatic environment, which showed that intestinal bacteria communities were dominated by a drug resistant microbiome. Our study provides new insight into the mechanism of enhanced natural transformation of ARGs by bisphenols, and highlights the investigations for unexpectedly-elevated antibiotic-resistant risks by structurally related environmental chemicals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
马士全发布了新的文献求助10
1秒前
1秒前
眼睛大傲之完成签到,获得积分10
1秒前
慕青应助ai白哥采纳,获得10
1秒前
桦奕兮完成签到 ,获得积分10
1秒前
2秒前
叮ding完成签到,获得积分10
3秒前
领导范儿应助端庄的豆芽采纳,获得10
4秒前
无奈的晴发布了新的文献求助10
5秒前
梁初见发布了新的文献求助10
5秒前
5秒前
5秒前
5秒前
完美世界应助桑叶采纳,获得10
5秒前
scup完成签到,获得积分10
6秒前
6秒前
8秒前
8秒前
赵志峰发布了新的文献求助10
8秒前
丘比特应助111采纳,获得10
10秒前
10秒前
ZZ发布了新的文献求助10
11秒前
11秒前
富婆嘉嘉子完成签到,获得积分10
12秒前
烧炭匠完成签到,获得积分10
12秒前
啊啊发布了新的文献求助10
12秒前
13秒前
13秒前
俏皮瑾瑜发布了新的文献求助20
13秒前
深情安青应助橙子采纳,获得30
14秒前
Akim应助会撒娇的芷烟采纳,获得10
15秒前
16秒前
17秒前
ding应助单薄绮露采纳,获得10
17秒前
18秒前
Yukangqian发布了新的文献求助10
19秒前
传奇3应助安的沛白采纳,获得10
20秒前
小二郎应助安的沛白采纳,获得10
20秒前
李爱国应助安的沛白采纳,获得10
20秒前
所所应助安的沛白采纳,获得10
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975871
求助须知:如何正确求助?哪些是违规求助? 3520207
关于积分的说明 11201502
捐赠科研通 3256611
什么是DOI,文献DOI怎么找? 1798403
邀请新用户注册赠送积分活动 877552
科研通“疑难数据库(出版商)”最低求助积分说明 806430