癌症干细胞
转移
Wnt信号通路
肿瘤微环境
生物
癌细胞
癌症研究
癌症
干细胞
氧化磷酸化
生物信息学
细胞生物学
神经科学
信号转导
肿瘤细胞
遗传学
生物化学
作者
Matthew Masoudi,Dilpreet Moti,Raha Masoudi,Abdul Auwal,MA Hossain,Tasfik Ul Haque Pronoy,Khan Mohammad Rashel,Vinod Gopalan,Farhadul Islam
标识
DOI:10.1016/j.bbadis.2024.167164
摘要
Cancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient deprivation and therapeutic stress, CSCs can transpose between glycolysis and oxidative phosphorylation (OXPHOS) metabolism. The mechanism behind the metabolic pathway switch in CSCs is not fully understood, however, some evidence suggests that the tumor microenvironment (TME) may play an influential role mediated by its release of signals, such as Wnt/β-catenin and Notch pathways, as well as a background of hypoxia. Exploring the factors that promote metabolic plasticity in CSCs offers the possibility of eventually developing therapies that may more effectively eliminate the crucial tumor cell subtype and alter the disease course substantially.
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