肝母细胞瘤
甲胎蛋白
医学
阿尔法(金融)
恶性肿瘤
化疗
内科学
胃肠病学
肿瘤科
外科
肝细胞癌
结构效度
患者满意度
作者
Monica Davini,Caroline Hastings,James Feusner
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-03-27
标识
DOI:10.1097/mph.0000000000002832
摘要
Hepatoblastoma is the most common liver malignancy in children. Treatment typically involves surgery and cisplatin-based chemotherapy. After therapy completion, children undergo repetitive surveillance imaging to screen for relapse, which occurs in <12% of cases. Monitoring for relapse has gradually shifted to serial determination of serum alpha-fetoprotein (AFP) alone as most cases have AFP elevation at the time of relapse. Little primary data supports, such a practice, however, and herein we present both our institutional experience with relapsed hepatoblastoma and a careful review of published literature on this topic. While serial AFP monitoring may suffice for most patients, certain clinical characteristics should give pause to the practitioner, when considering posttreatment monitoring with serum AFP alone.
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