• Snake bites are a underestimated public health problem in many tropical and subtropical countries. • The misguided treatments of snakebite wounds can cause more harm than the snakebite itself. • There are no unified guidelines for emergency management of common snakebite wounds. • Novel and effective approaches for snakebite wounds management are being studied worldwide. • Liuhedan and Comfeel® Wound Dressing showed comparable effectiveness in reducing snakebite wound swelling, surpassing the effects observed in the magnesium sulfate group.