鞣花酸
结直肠癌
细胞凋亡
癌症研究
癌症
细胞周期
化学
细胞生长
生物
生物化学
分子生物学
抗氧化剂
多酚
遗传学
作者
Jinlu Zhao,Guodong Li,Yi Ren,Zhicheng Zhang,Hongsheng Chen,Haopeng Zhang,Xingyu Zhao,Wang Li,Anne E. Justice,Guan Xue,Ming Liu
出处
期刊:Anti-Cancer Drugs
[Ovid Technologies (Wolters Kluwer)]
日期:2023-03-24
卷期号:34 (10): 1112-1121
被引量:2
标识
DOI:10.1097/cad.0000000000001513
摘要
The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated anticancer effects using the human colon cancer HCT-116 cell line. After 72 h of ellagic acid treatment, a total of 206 long noncoding RNAs (lncRNAs) with differential expression greater than 1.5-fold were identified (115 down-regulated and 91 up-regulated). Furthermore, the co-expression network analysis of differentially expressed lncRNA and mRNA showed that differential expressed lncRNA might be the target of ellagic acid activity in inhibiting CRC.
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