Exposure of Tibetan pregnant women to antibiotics in China: A biomonitoring-based study

尿 抗生素 肌酐 生物监测 危险系数 医学 动物科学 生理学 兽医学 毒理 环境卫生 内科学 生物 化学 健康风险 微生物学 环境化学
作者
Yuanping Wang,Yue Chen,Yangzong Gesang,Zichen Yang,Yi Wang,Ke Zhao,Minghui Han,Chunxia Li,Ouzhu Luobu,Jiwei Wang,Hexing Wang,Qingwu Jiang
出处
期刊:Environmental Pollution [Elsevier BV]
卷期号:325: 121439-121439 被引量:4
标识
DOI:10.1016/j.envpol.2023.121439
摘要

Tibetan people are one Chinese ethnic minority living in Qinghai-Tibet Plateau with an average altitude of more than 4500 m. High altitude could cause a different antibiotic exposure, but relevant information is limited in Tibetan people. We investigated 476 Tibetan pregnant women in Lhasa, Tibet in 2021 and measured 30 antibiotics from five categories in urine, including 13 veterinary antibiotics (VAs), five human antibiotics (HAs), and 12 human/veterinary antibiotics (H/VAs). Food consumption was investigated by a brief food frequency questionnaire. Health risk was assessed by hazard quotient (HQ) and hazard index (HI) based on acceptable daily intakes (ADIs). All antibiotics were overall detected in 34.7% of urine samples with the 75th percentile concentration of 0.19 ng/mL (0.35 μg/g creatinine). HAs, VAs, and H/VAs were respectively detected in 5.3%, 13.0%, and 25.0% of urine samples, with the 95th percentiles of 0.01 ng/mL (0.01 μg/g creatinine), 0.50 ng/mL (0.99 μg/g creatinine), and 3.58 ng/mL (5.02 μg/g creatinine), respectively. Maternal age, smoking of family members, and housework time were associated with detection frequencies of HAs, VAs, or sum of all antibiotics. Pregnant women with a more frequent consumption of fresh milk, egg, yoghourt, poultry meat, and fish had a higher detection frequency of VAs or H/VAs. Only ciprofloxacin and tetracycline had a HQ of larger than one based on microbiological effect in 1.26% and 0.21% of pregnant women, respectively and a HI of larger than one was found in 1.47% of pregnant women. The findings suggested that there was an evident antibiotic exposure from various sources in Tibetan pregnant women with some basic characteristics of pregnant women as potential predictors and several animal-derived food items were important sources of exposure to antibiotic with a fraction of pregnant women in the health risk related to microbiological disruption of gut microbiota.
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