增强子
生物
转录因子
细胞生物学
增强子rna
电池类型
抑制因子
基因表达调控
基因表达
心理压抑
抄写(语言学)
细胞
分子生物学
基因
遗传学
哲学
语言学
作者
Lilan Hong,Byron Rusnak,Clint S. Ko,Shou-Ling Xu,Xi He,Dengying Qiu,Shuli Kang,Jose L. Pruneda‐Paz,Adrienne Roeder
出处
期刊:The Plant Cell
[Oxford University Press]
日期:2023-02-23
卷期号:35 (6): 2349-2368
被引量:1
标识
DOI:10.1093/plcell/koad054
摘要
Abstract Proper cell-type identity relies on highly coordinated regulation of gene expression. Regulatory elements such as enhancers can produce cell type-specific expression patterns, but the mechanisms underlying specificity are not well understood. We previously identified an enhancer region capable of driving specific expression in giant cells, which are large, highly endoreduplicated cells in the Arabidopsis thaliana sepal epidermis. In this study, we use the giant cell enhancer as a model to understand the regulatory logic that promotes cell type-specific expression. Our dissection of the enhancer revealed that giant cell specificity is mediated primarily through the combination of two activators and one repressor. HD-ZIP and TCP transcription factors are involved in the activation of expression throughout the epidermis. High expression of HD-ZIP transcription factor genes in giant cells promoted higher expression driven by the enhancer in giant cells. Dof transcription factors repressed the activity of the enhancer such that only giant cells maintained enhancer activity. Thus, our data are consistent with a conceptual model whereby cell type-specific expression emerges from the combined activities of three transcription factor families activating and repressing expression in epidermal cells.
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