Management of adult generalized pustular psoriasis using biologics: A systematic review

To the Editor: Generalized pustular psoriasis (GPP) is a rare inflammatory disease linked to IL36RN gene mutations, which results in a deficiency of the interleukin 36 receptor antagonist (DITRA). 1 Gooderham M.J. Van Voorhees A.S. Lebwohl M.G. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019; 15: 907-919https://doi.org/10.1080/1744666X.2019.1648209 Crossref PubMed Scopus (107) Google Scholar Currently, no consensus-based guidelines or universally accepted treatments exist. This systematic review aims to highlight the efficacy and safety of systemic biologics for GPP in adults.