Patient profiling to predict response to bronchial thermoplasty in patients with severe asthma

支气管热成形术 医学 哮喘 重症监护医学 内科学 气道阻力
作者
Satoshi Ano,Norihiro Kikuchi,Masashi Matsuyama,Nobuyuki Hizawa
出处
期刊:Respiratory investigation [Elsevier BV]
卷期号:61 (6): 675-681 被引量:1
标识
DOI:10.1016/j.resinv.2023.07.003
摘要

Bronchial thermoplasty is the only device-based nonpharmacological treatment approach for severe asthma. Current guidelines are cautious in recommending bronchial thermoplasty because of unknown patient response prediction. Recent research on bronchial thermoplasty includes up-to-date, state-of-the-art, and recent-advances reviews. However, these reviews provide a broad and general discussion on equipment, technique, patient selection, and patient management, with little evaluation of the predictors of a beneficial response. Predicting an optimal response to bronchial thermoplasty in patients with severe asthma remains elusive. The lack of reliable predictive markers means that bronchial thermoplasty remains a last-line treatment and makes profiling for predicting the response or efficacy a topic of study. Genetic changes are associated with airway remodeling. A gap in the literature exists regarding patient profiling to predict the response to bronchial thermoplasty in patients with severe asthma. Therefore, recently published omics data and genetic associations regarding the response to bronchial thermoplasty therapy should be reviewed. We present an up-to-date review of recent publications profiling the response to bronchial thermoplasty in patients with severe asthma.
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