小RNA
医学
败血症
诊断生物标志物
内科学
肿瘤科
多元分析
新生儿败血症
生物标志物
诊断准确性
生物
基因
遗传学
作者
Nashwa El-Khazragy⃰,Noura Mostafa Mohamed,Mohamed F. Mostafa,Mostafa Elnakib,Eman H.A. Hemida,A. Ben Salah,Nesma Mohamed Fawzy,Gehan Safwat,Mennatallah M. Emam,Nievin Ahmed Mahran,Dina Rabie
标识
DOI:10.1016/j.diagmicrobio.2023.116053
摘要
The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.
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