亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Aberrant spontaneous static and dynamic amplitude of low‐frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment

神经心理学 邦费罗尼校正 静息状态功能磁共振成像 磁共振成像 默认模式网络 认知 心脏病学 医学 认知功能衰退 神经影像学 内科学 听力学 心理学 神经科学 疾病 痴呆 放射科 数学 统计
作者
Xulian Zhang,Zhigang Wang,Darui Zheng,Xuan Cao,Wenzhang Qi,Qianqian Yuan,Da Zhang,Xuhong Liang,Yiming Ruan,Shaojun Zhang,Weijie Tang,Qingling Huang,Chen Xue
出处
期刊:Brain and behavior [Wiley]
卷期号:13 (12) 被引量:5
标识
DOI:10.1002/brb3.3279
摘要

Abstract Background Cerebral small vessel disease (CSVD) is considered an age‐related degenerative neurological disorder and the most common risk factor for vascular cognitive impairment (VCI). The amplitude of fluctuation of low frequency (ALFF) can detect altered intrinsic brain activity in CSVD. This study explored the static and dynamic ALFFs in the early stage of CSVD with (CSVD‐M) or without (CSVD‐W) mild cognitive impairment (MCI) in these patients and how these changes contribute to cognitive deterioration. Methods Thirty consecutive CSVD cases and 18 healthy controls (HC) were included in this study. All the participants underwent a 3D magnetization‐prepared rapid gradient‐echo (MPRAGE) sequence to obtain structural T1‐weighted images. Simultaneous multislice imaging 5(SMS5) was used for resting‐state functional MRI (rs‐fMRI), and Data Processing and Analysis of Brain Imaging software helped determine static ALFF (sALFF). The dynamic ALFF (dALFF) was calculated using the sliding window method of DynamicBC software. Analysis of Covariance (ANCOVA) and two‐sample t ‐test were used to evaluate the sALFF and temporal variability of dALFF among the three groups. The subjects were rated on a broad standard neuropsychological scale. Partial correlation analysis was used to evaluate the correlation between sALFF and dALFF variability and cognition (Bonferroni correction, statistical threshold set at p < .05). Results Compared with HCs, the CSVD‐M group indicated decreased sALFF values in the bilateral cerebellum posterior lobe (CPL) and the left inferior Parietal Lobule (IPL), with increased sALFF values in the right SFG. For dALFF analysis, the CSVD‐W group had significant dALFF variability in the right fusiform gyrus compared with HC. Moreover, the postcentral gyrus (PoCG) was significantly high in the CSVD‐W group. While in the CSVD‐M group, the bilateral paracentral lobules (PL) revealed significantly elevated dALFF variability and low dALFF variability in the left CPL and right IPL compared with HCs. The CSVD‐M group had high dALFF variability in the bilateral PL but low dALFF variability in the left middle temporal gyrus (MTG) and right PoCG compared with the CSVD‐W group. The partial correlation analysis indicated that dALFF variability in the left MTG was positively associated with EM ( r = 0.713, p = .002) in CSVD‐W and CSVD‐M groups. In the groups with CSVD‐M and HC, altered dALFF variability in the bilateral PL was negatively correlated with EM ( r = −0.560, p = .002). Conclusion There were significant changes in sALFF and dALFF variability in CSVD patients. Abnormal spontaneous static and dynamic ALFFs may provide new insights into cognitive dysfunction in CSVD with MCI and may be valuable biomarkers for early diagnosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
老石完成签到 ,获得积分10
3秒前
13秒前
CipherSage应助科研通管家采纳,获得10
1分钟前
彭于晏应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
火星上向珊完成签到,获得积分10
1分钟前
1分钟前
wdxx发布了新的文献求助30
1分钟前
liufan完成签到 ,获得积分10
2分钟前
lmplzzp完成签到,获得积分10
2分钟前
橙子味的邱憨憨完成签到 ,获得积分10
2分钟前
杪夏二八完成签到 ,获得积分10
2分钟前
wdxx完成签到,获得积分10
2分钟前
649981108发布了新的文献求助10
3分钟前
3分钟前
649981108完成签到,获得积分10
3分钟前
3分钟前
研友_892kOL完成签到,获得积分10
3分钟前
脑洞疼应助李小猫采纳,获得10
3分钟前
4分钟前
李小猫完成签到,获得积分10
4分钟前
4分钟前
李小猫发布了新的文献求助10
4分钟前
4分钟前
4分钟前
5分钟前
6分钟前
7分钟前
Tiger完成签到,获得积分10
7分钟前
7分钟前
7分钟前
Ma发布了新的文献求助10
7分钟前
7分钟前
7分钟前
科研通AI5应助Ma采纳,获得10
7分钟前
彼岸花开发布了新的文献求助10
8分钟前
8分钟前
易四夕发布了新的文献求助10
8分钟前
9分钟前
科研通AI2S应助科研通管家采纳,获得10
9分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167214
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638