癌变
肿瘤微环境
炎症
肝X受体
免疫系统
生物
癌症研究
细胞因子
肿瘤进展
细胞生物学
免疫学
核受体
转录因子
癌症
遗传学
基因
作者
Heng Zhang,Jing Wang,Jiang Sun,Qiang Wang,Lanfang Guo,Xiaoli Ju
标识
DOI:10.1080/14728222.2023.2264513
摘要
Liver X receptors (LXRs) have emerged as novel targets for tumor treatment. LXRs within the tumor microenvironment show the capacity to impact tumorigenesis and tumor development by regulating the infiltration of immune cells and release of cytokines to moderate inflammation.In this review, we present a systematic description of recent progress in understanding the impact of LXRs on the tumor microenvironment and tumorigenesis. We also summarize the antitumor effects mediated by LXRs via their regulation of cytokine expression. Additionally, we discuss the limitations of LXR research in tumor studies to date.Previous studies have demonstrated abnormal LXR expression in tumor tissues, and activation of LXRs has been shown to inhibit tumorigenesis and promote apoptosis in tumor cells. However, LXRs can also affect tumorigenesis by regulating immune cell functions within the tumor immune microenvironment. By summarizing the impact of LXRs on immune cells, we provide new insights into the multifaceted nature of LXRs as antitumor targets.
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