Synthesis of Isoquinolinediones via the Radical Addition/Cyclization of N‐Alkyl‐N‐methacryloylbenzamides with Monoalkyl Oxalates

Abstract A photocatalytic reaction of N‐alkyl‐N‐methacryloylbenzamides with monoalkyl oxalates is described. Monoalkyl oxalates undergo single‐electron oxidation/CO 2 extrusion to generate alkoxycarbonyl radicals, followed by the addition and subsequent cyclization to give alkoxycarbonyl substituted isoquinolinediones. A wide variety of monoalkyl oxalates were amenable in this protocol, affording various alkoxycarbonyl substituted isoquinolinediones.