丁酸盐
肠道菌群
免疫系统
失调
炎症性肠病
代谢物
生物
溃疡性结肠炎
免疫学
平衡
势垒函数
先天免疫系统
疾病
微生物学
医学
细胞生物学
内科学
生物化学
发酵
作者
Neeraja Recharla,Ramasatyavini Geesala,Xuan-Zheng P. Shi
标识
DOI:10.20944/preprints202304.0501.v1
摘要
Intestinal commensal microbes, called the gut microbiota, play a critical role in host immune homeostasis through active microbial metabolites and innate and adaptive immune responses. Dysbiosis or imbalance of the gut microbiota composition is associated with inflammatory bowel disease (IBD) which includes Crohn’s disease and ulcerative colitis. The incidence and prevalence rates of IBD have been increasing worldwide. It is well recognized that butyrate, a microbial metabolite of diet fibers, is a major energy source for colonocytes and plays a crucial role in regulating immune function and maintaining epithelial barrier function and intestinal homeostasis. Emerging evidence suggests that butyrate might be a potential therapeutic agent to treat IBD. In this review, we discuss about gut microbial metabolites, particularly butyrate, the synthesis and metabolism of butyrate, mechanisms of butyrate in immune and epithelial barrier function. Furthermore, we review the current research on various therapeutic implications of butyrate in IBD.
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