区域选择性
化学
废止
组合化学
催化作用
茚
基质(水族馆)
级联反应
立体化学
药物化学
有机化学
海洋学
地质学
作者
Koushik Naskar,Sudip Karmakar,Imtiaj Mondal,Writhabrata Sarkar,Shantonu Roy,Anupam Singha Roy,Indubhusan Deb
摘要
We report an unprecedented atom-economic one-pot Cp*Rh(III)-catalyzed regioselective [3+2]-spiroannulation reaction between dibenz(ox)azepines and ynones, allowing the synthesis of biologically relevant novel spirocyclic dibenz(ox)azepines under operationally simple and mild reaction conditions. The reaction proceeds without any silver additive or external oxidant implementing a redox-neutral pathway. A broad substrate scope with diverse functional group tolerance permitted the regioselective synthesis of a wide spectrum of indene-containing spirocyclic dibenz(ox)azepines in good to excellent yields. Also, we showcased detailed mechanistic studies to justify the formation of spirocycles. In addition, the synthetic utility of this process was also demonstrated by the modular synthesis of various steroid conjugates.
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